人 Beta Amyloid 1-40 抗体对

靶点名称

Beta Amyloid 1-40

蛋白名称

amyloid beta precursor protein

蛋白别名

Amyloid-beta precursor protein; APP; ABPP; APPI; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; Amyloid precursor protein; Amyloid-beta; A4) precursor protein; Amyloid-beta A4 protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II) [Cleaved into: N-APP; Soluble APP-alpha; S-APP-alpha; Soluble APP-beta; S-APP-beta; C99; Beta-secretase C-terminal fragment; Beta-CTF; Amyloid-beta protein 42; Abeta42; Beta-APP42; Amyloid-beta protein 40; Abeta40; Beta-APP40; C83; Alpha-secretase C-terminal fragment; Alpha-CTF; P3(42; P3(40; C80; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; AICD-59; AID(59); Gamma-CTF(59); Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; AICD-57; AID(57); Gamma-CTF(57); Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID(50); Gamma-CTF(50); C31]

靶点基因名

APP

基因别名

A4; AD1

UniProt

P05067

来源物种

Homo sapiens (Human)

物种反应性

Human

背景介绍

Amyloid-beta (1-40), abbreviated as Aβ(1-40), is a 40-residue peptide derived from the amyloid precursor protein (APP) and is involved in the pathogenesis of Alzheimer's disease (AD). It is one of the two main C-terminal variants of the amyloid-beta peptide, along with Aβ(1-42). Both Aβ(1-40) and Aβ(1-42) form aggregates and deposits in the AD brain, contributing to the formation of senile plaques. Unaggregated soluble Aβ(1-40) can also exhibit toxic effects and influence behavior and memory. Additionally, Aβ(1-40) has been shown to interact with synaptic structures such as postsynaptic density-95 (PSD-95), leading to its degradation and affecting synaptic function.