抗人 beta-2-Microglobulin 抗体对
01AB00712
Beta-2 microglobulin (B2M) is a component of major histocompatibility complex class I (MHC-I) molecules, which are present on the surface of all nucleated cells. It plays a crucial role in the immune system by presenting peptides derived from intracellular proteins to cytotoxic T cells. Elevated levels of B2M are associated with various diseases, including multiple myeloma, lymphoma, chronic kidney disease, and cardiovascular diseases. In chronic kidney disease, increased B2M levels in blood and urine indicate glomerular or tubular dysfunction. Additionally, B2M has been linked to an increased risk of coronary heart disease, stroke, and all-cause mortality, potentially due to its pro-inflammatory and pro-angiogenic properties. Notably, in patients undergoing long-term hemodialysis, B2M can aggregate into amyloid fibers, leading to dialysis-related amyloidosis.
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技术参数
- 靶点基因名
- B2M
- 蛋白别名
- beta-2-microglobulin; beta-2-Microglobulin
- UniProt
- P61769
- 物种
- Human
产品详情
- 靶点名称
- beta-2-Microglobulin
- 蛋白名称
- beta-2-microglobulin
- 蛋白别名
- Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
- 靶点基因名
- B2M
- UniProt
- P61769
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Beta-2 microglobulin (B2M) is a component of major histocompatibility complex class I (MHC-I) molecules, which are present on the surface of all nucleated cells. It plays a crucial role in the immune system by presenting peptides derived from intracellular proteins to cytotoxic T cells. Elevated levels of B2M are associated with various diseases, including multiple myeloma, lymphoma, chronic kidney disease, and cardiovascular diseases. In chronic kidney disease, increased B2M levels in blood and urine indicate glomerular or tubular dysfunction. Additionally, B2M has been linked to an increased risk of coronary heart disease, stroke, and all-cause mortality, potentially due to its pro-inflammatory and pro-angiogenic properties. Notably, in patients undergoing long-term hemodialysis, B2M can aggregate into amyloid fibers, leading to dialysis-related amyloidosis.