人 BEND2 抗体对
01AB03089
BEN domain-containing protein 2 (BEND2) is an X-linked nuclear protein characterized by two C-terminal BEN domains that mediate DNA and protein interactions involved in transcriptional repression and chromatin remodeling. It regulates gene expression by modulating histone marks like H3K4me3. BEND2 is highly expressed during spermatogenesis, where it is essential for meiotic synapsis and DNA double-strand break repair. In pathology, BEND2 is implicated in CNS tumorigenesis, notably in astroblastoma where MN1-BEND2 fusions function as oncogenic drivers, highlighting its role in chromatin-associated malignancy.
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技术参数
- 靶点基因名
- BEND2
- 基因别名
- CXorf20
- 蛋白别名
- BEN domain containing 2; BEND2
- UniProt
- Q8NDZ0
- 物种
- Human
产品详情
- 靶点名称
- BEND2
- 蛋白名称
- BEN domain containing 2
- 蛋白别名
- BEN domain-containing protein 2
- 靶点基因名
- BEND2
- 基因别名
- CXorf20
- UniProt
- Q8NDZ0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
BEN domain-containing protein 2 (BEND2) is an X-linked nuclear protein characterized by two C-terminal BEN domains that mediate DNA and protein interactions involved in transcriptional repression and chromatin remodeling. It regulates gene expression by modulating histone marks like H3K4me3. BEND2 is highly expressed during spermatogenesis, where it is essential for meiotic synapsis and DNA double-strand break repair. In pathology, BEND2 is implicated in CNS tumorigenesis, notably in astroblastoma where MN1-BEND2 fusions function as oncogenic drivers, highlighting its role in chromatin-associated malignancy.