人 BD-Tau125 抗体对
01AB03509
BD-Tau125 represents a brain-derived tau biomarker designed to selectively quantify central nervous system-specific tau isoforms while excluding interference from peripherally expressed forms known as Big Tau. This specificity is achieved by using antibody strategies that target epitopes absent in the exon 4A-containing isoforms that are predominant in peripheral tissues. By isolating CNS-specific signals, this marker aims to provide a more accurate biochemical assessment of neurodegeneration compared to traditional total tau assays, which can be confounded by peripheral noise. Clinically, it functions as a marker of neurodegeneration within biological frameworks, showing elevation in symptomatic Alzheimer's disease and correlating with other markers of neuronal injury, serving to distinguish brain-specific pathology from systemic sources.
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技术参数
- 靶点基因名
- MAPT
- 基因别名
- MAPTL; MTBT1; TAU
- 蛋白别名
- Microtubule-associated protein tau; BD-Tau125
- UniProt
- P10636-8
- 物种
- Human
产品详情
- 靶点名称
- BD-Tau125
- 蛋白名称
- Microtubule-associated protein tau
- 靶点基因名
- MAPT
- 基因别名
- MAPTL; MTBT1; TAU
- UniProt
- P10636-8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
BD-Tau125 represents a brain-derived tau biomarker designed to selectively quantify central nervous system-specific tau isoforms while excluding interference from peripherally expressed forms known as Big Tau. This specificity is achieved by using antibody strategies that target epitopes absent in the exon 4A-containing isoforms that are predominant in peripheral tissues. By isolating CNS-specific signals, this marker aims to provide a more accurate biochemical assessment of neurodegeneration compared to traditional total tau assays, which can be confounded by peripheral noise. Clinically, it functions as a marker of neurodegeneration within biological frameworks, showing elevation in symptomatic Alzheimer's disease and correlating with other markers of neuronal injury, serving to distinguish brain-specific pathology from systemic sources.