人 BCL6 抗体对
01AB02919
B-cell lymphoma 6 protein (BCL6) is a transcriptional repressor that belongs to the BTB/POZ (Broad-complex, Tramtrack, and Bric-à-brac/Pox virus and Zinc finger) family of proteins. It contains an N-terminal BTB/POZ domain, a central transcriptional repressor domain, and C-terminal zinc finger motifs that enable DNA binding. BCL6 is a master regulator of humoral immunity, playing a crucial role in the initiation and maintenance of germinal centers (GCs) during the immune response. It promotes the survival, proliferation, and differentiation of GC B cells by repressing genes involved in cell cycle arrest, apoptosis, and terminal differentiation. Dysregulation of BCL6 has been strongly implicated in the pathogenesis of B-cell lymphomas, particularly diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). Overexpression of BCL6 in these cancers contributes to uncontrolled proliferation, genomic instability, and immune evasion.
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技术参数
- 靶点基因名
- BCL6
- 基因别名
- BCL5; LAZ3; ZBTB27; ZNF51
- 蛋白别名
- BCL6 transcription repressor; BCL6
- UniProt
- P41182
- 物种
- Human
产品详情
- 靶点名称
- BCL6
- 蛋白名称
- BCL6 transcription repressor
- 蛋白别名
- B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51
- 靶点基因名
- BCL6
- 基因别名
- BCL5; LAZ3; ZBTB27; ZNF51
- UniProt
- P41182
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
B-cell lymphoma 6 protein (BCL6) is a transcriptional repressor that belongs to the BTB/POZ (Broad-complex, Tramtrack, and Bric-à-brac/Pox virus and Zinc finger) family of proteins. It contains an N-terminal BTB/POZ domain, a central transcriptional repressor domain, and C-terminal zinc finger motifs that enable DNA binding. BCL6 is a master regulator of humoral immunity, playing a crucial role in the initiation and maintenance of germinal centers (GCs) during the immune response. It promotes the survival, proliferation, and differentiation of GC B cells by repressing genes involved in cell cycle arrest, apoptosis, and terminal differentiation. Dysregulation of BCL6 has been strongly implicated in the pathogenesis of B-cell lymphomas, particularly diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). Overexpression of BCL6 in these cancers contributes to uncontrolled proliferation, genomic instability, and immune evasion.