人 BCL2L2 抗体对
01AB01637
BCL2 like 2 (BCL2L2) is an anti-apoptotic member of the BCL-2 family that promotes cell survival by sequestering pro-apoptotic BH3-only proteins, thereby preventing mitochondrial outer membrane permeabilization and subsequent caspase activation. It is prominently expressed in the nervous system and testis, where it supports the survival of neurotrophin-dependent neurons and postmitotic Sertoli cells. BCL2L2 interacts with survival pathways such as NF-kappaB and TNFR1 signaling to block BAX-mediated apoptosis. Clinically, dysregulation of BCL2L2 is associated with cancer cell survival and therapeutic resistance. It is also linked to glioma susceptibility and oculopharyngeal muscular dystrophy, making it a significant target for the development of pro-apoptotic cancer therapies.
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技术参数
- 靶点基因名
- BCL2L2,BCL2L2-PABPN1
- 基因别名
- BCLW; KIAA0271
- 蛋白别名
- BCL2 like 2,BCL2L2-PABPN1 readthrough; BCL2L2
- UniProt
- Q92843
- 物种
- Human
产品详情
- 靶点名称
- BCL2L2
- 蛋白名称
- BCL2 like 2,BCL2L2-PABPN1 readthrough
- 蛋白别名
- Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W
- 靶点基因名
- BCL2L2,BCL2L2-PABPN1
- 基因别名
- BCLW; KIAA0271
- UniProt
- Q92843
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
BCL2 like 2 (BCL2L2) is an anti-apoptotic member of the BCL-2 family that promotes cell survival by sequestering pro-apoptotic BH3-only proteins, thereby preventing mitochondrial outer membrane permeabilization and subsequent caspase activation. It is prominently expressed in the nervous system and testis, where it supports the survival of neurotrophin-dependent neurons and postmitotic Sertoli cells. BCL2L2 interacts with survival pathways such as NF-kappaB and TNFR1 signaling to block BAX-mediated apoptosis. Clinically, dysregulation of BCL2L2 is associated with cancer cell survival and therapeutic resistance. It is also linked to glioma susceptibility and oculopharyngeal muscular dystrophy, making it a significant target for the development of pro-apoptotic cancer therapies.