抗人 BCL2L13 抗体对
01AB03841
Bcl-2-like protein 13 (BCL2L13), also known as Bcl-rambo, is a member of the Bcl-2 protein family, primarily localized to the mitochondria. It consists of four conserved Bcl-2 homology domains and a single transmembrane domain, which facilitates its mitochondrial localization. Unlike other Bcl-2 family members, BCL2L13 can induce apoptosis independently of its BH domains, suggesting a unique mechanism of action. It interacts with components of the mitochondrial permeability transition pore, promoting the release of pro-apoptotic factors. Dysregulation of BCL2L13 has been linked to various cancers, including childhood acute lymphoblastic leukemia (ALL) and glioblastoma multiforme (GBM). In GBM, BCL2L13 has been shown to inhibit apoptosis by interacting with ceramide synthases, thus blocking their pro-apoptotic activity.
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技术参数
- 靶点基因名
- BCL2L13
- 基因别名
- MIL1
- 蛋白别名
- BCL2 like 13; BCL2L13
- UniProt
- Q9BXK5
- 物种
- Human
产品详情
- 靶点名称
- BCL2L13
- 蛋白名称
- BCL2 like 13
- 蛋白别名
- Bcl-2-like protein 13; Bcl2-L-13; Bcl-rambo; Protein Mil1
- 靶点基因名
- BCL2L13
- 基因别名
- MIL1
- UniProt
- Q9BXK5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Bcl-2-like protein 13 (BCL2L13), also known as Bcl-rambo, is a member of the Bcl-2 protein family, primarily localized to the mitochondria. It consists of four conserved Bcl-2 homology domains and a single transmembrane domain, which facilitates its mitochondrial localization. Unlike other Bcl-2 family members, BCL2L13 can induce apoptosis independently of its BH domains, suggesting a unique mechanism of action. It interacts with components of the mitochondrial permeability transition pore, promoting the release of pro-apoptotic factors. Dysregulation of BCL2L13 has been linked to various cancers, including childhood acute lymphoblastic leukemia (ALL) and glioblastoma multiforme (GBM). In GBM, BCL2L13 has been shown to inhibit apoptosis by interacting with ceramide synthases, thus blocking their pro-apoptotic activity.