抗人 BCL2L11 抗体对
01AB00732
Bcl-2-like protein 11 (BCL2L11), also known as BIM, is a pro-apoptotic member of the BCL-2 protein family. It contains a BH3 domain and interacts with other BCL-2 family proteins to promote apoptosis. BCL2L11 exists in multiple isoforms, with BimL and BimS being more potent inducers of cell death than BimEL. The protein is regulated at transcriptional, translational, and post-translational levels, playing crucial roles in immune responses and tissue homeostasis. BCL2L11 is involved in various cellular processes, including anoikis and autophagy regulation. Dysregulation of BCL2L11 has been implicated in several diseases, including cancer and autoimmune disorders. In cancer, suppression of BCL2L11 expression can contribute to tumor progression and metastasis. Additionally, genetic variants in BCL2L11 have been associated with an increased risk of developing ulcerative forms of Buruli ulcer, a mycobacterial skin infection.
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技术参数
- 靶点基因名
- BCL2L11
- 基因别名
- BIM
- 蛋白别名
- Bcl-2-like protein 11; BCL2L11
- UniProt
- O43521-2
- 物种
- Human
产品详情
- 靶点名称
- BCL2L11
- 蛋白名称
- Bcl-2-like protein 11
- 蛋白别名
- Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death
- 靶点基因名
- BCL2L11
- 基因别名
- BIM
- UniProt
- O43521-2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Bcl-2-like protein 11 (BCL2L11), also known as BIM, is a pro-apoptotic member of the BCL-2 protein family. It contains a BH3 domain and interacts with other BCL-2 family proteins to promote apoptosis. BCL2L11 exists in multiple isoforms, with BimL and BimS being more potent inducers of cell death than BimEL. The protein is regulated at transcriptional, translational, and post-translational levels, playing crucial roles in immune responses and tissue homeostasis. BCL2L11 is involved in various cellular processes, including anoikis and autophagy regulation. Dysregulation of BCL2L11 has been implicated in several diseases, including cancer and autoimmune disorders. In cancer, suppression of BCL2L11 expression can contribute to tumor progression and metastasis. Additionally, genetic variants in BCL2L11 have been associated with an increased risk of developing ulcerative forms of Buruli ulcer, a mycobacterial skin infection.