抗人 BARHL1 抗体对
01AB02383
BarH like homeobox 1 (BARHL1) is a homeodomain transcription factor that regulates gene expression by binding to sequence-specific DNA targets. It is primarily expressed in restricted neural domains, including the diencephalon, cerebellar granule cells, and inner ear hair cells, where it governs neuronal differentiation, migration, and survival. The protein structure features a conserved homeodomain flanked by acidic and proline-rich regions that facilitate its interaction with the RNA polymerase II transcriptional machinery. BARHL1 is essential for the development of the central nervous system and the sensory perception of sound, playing a specialized role in the maturation of rhombic lip-derived neurons and dorsal spinal interneurons.
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技术参数
- 靶点基因名
- BARHL1
- 蛋白别名
- BarH like homeobox 1; BARHL1
- UniProt
- Q9BZE3
- 物种
- Human
产品详情
- 靶点名称
- BARHL1
- 蛋白名称
- BarH like homeobox 1
- 蛋白别名
- BarH-like 1 homeobox protein
- 靶点基因名
- BARHL1
- UniProt
- Q9BZE3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
BarH like homeobox 1 (BARHL1) is a homeodomain transcription factor that regulates gene expression by binding to sequence-specific DNA targets. It is primarily expressed in restricted neural domains, including the diencephalon, cerebellar granule cells, and inner ear hair cells, where it governs neuronal differentiation, migration, and survival. The protein structure features a conserved homeodomain flanked by acidic and proline-rich regions that facilitate its interaction with the RNA polymerase II transcriptional machinery. BARHL1 is essential for the development of the central nervous system and the sensory perception of sound, playing a specialized role in the maturation of rhombic lip-derived neurons and dorsal spinal interneurons.