人 BANK1 抗体对
01AB03944
B cell scaffold protein with ankyrin repeats 1 (BANK1) is a crucial protein primarily expressed in B cells, where it plays significant roles in various signaling pathways, including B cell receptor (BCR) signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling. It is encoded by the BANK1 gene located on chromosome 4 and contains several functional domains, including ankyrin repeat-like motifs and a coiled-coil domain. Genetic variants of BANK1 have been associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE), where certain polymorphisms influence its expression and functionality. BANK1 facilitates calcium mobilization in B cells and promotes Lyn-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors, highlighting its integral role in B cell activation and immune response modulation.
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技术参数
- 靶点基因名
- BANK1
- 蛋白别名
- B cell scaffold protein with ankyrin repeats 1; BANK1
- UniProt
- Q8NDB2
- 物种
- Human
产品详情
- 靶点名称
- BANK1
- 蛋白名称
- B cell scaffold protein with ankyrin repeats 1
- 蛋白别名
- B-cell scaffold protein with ankyrin repeats
- 靶点基因名
- BANK1
- UniProt
- Q8NDB2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
B cell scaffold protein with ankyrin repeats 1 (BANK1) is a crucial protein primarily expressed in B cells, where it plays significant roles in various signaling pathways, including B cell receptor (BCR) signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling. It is encoded by the BANK1 gene located on chromosome 4 and contains several functional domains, including ankyrin repeat-like motifs and a coiled-coil domain. Genetic variants of BANK1 have been associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE), where certain polymorphisms influence its expression and functionality. BANK1 facilitates calcium mobilization in B cells and promotes Lyn-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors, highlighting its integral role in B cell activation and immune response modulation.