人 BAG4 抗体对
01AB04176
BAG family molecular chaperone regulator 4 (BAG4) is a protein that functions as a co-chaperone, primarily involved in the regulation of cellular stress responses and protein homeostasis. It contains a BAG domain that interacts with heat shock proteins, particularly Hsp70, to modulate their activity and influence protein folding and degradation processes. BAG4 is known to inhibit apoptosis by interacting with various cell death-related proteins, including BCL-2 and tumor necrosis factor receptor (TNF-R1), thereby negatively regulating apoptosis signaling pathways. Dysregulation of BAG4 has been implicated in several diseases, elevated levels of BAG4 are associated with poor prognosis in malignancies such as breast cancer and multiple myeloma, where it may contribute to tumor cell survival and resistance to therapy. Additionally, BAG4's involvement in inflammatory responses suggests its potential role in autoimmune diseases.
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技术参数
- 靶点基因名
- BAG4
- 基因别名
- SODD
- 蛋白别名
- BAG cochaperone 4; BAG4
- UniProt
- O95429
- 物种
- Human
产品详情
- 靶点名称
- BAG4
- 蛋白名称
- BAG cochaperone 4
- 蛋白别名
- BAG family molecular chaperone regulator 4; BAG-4; Bcl-2-associated athanogene 4; Silencer of death domains
- 靶点基因名
- BAG4
- 基因别名
- SODD
- UniProt
- O95429
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
BAG family molecular chaperone regulator 4 (BAG4) is a protein that functions as a co-chaperone, primarily involved in the regulation of cellular stress responses and protein homeostasis. It contains a BAG domain that interacts with heat shock proteins, particularly Hsp70, to modulate their activity and influence protein folding and degradation processes. BAG4 is known to inhibit apoptosis by interacting with various cell death-related proteins, including BCL-2 and tumor necrosis factor receptor (TNF-R1), thereby negatively regulating apoptosis signaling pathways. Dysregulation of BAG4 has been implicated in several diseases, elevated levels of BAG4 are associated with poor prognosis in malignancies such as breast cancer and multiple myeloma, where it may contribute to tumor cell survival and resistance to therapy. Additionally, BAG4's involvement in inflammatory responses suggests its potential role in autoimmune diseases.