人 BACH1 抗体对
01AB02902
Transcription regulator protein BACH1 (BACH1) is a member of the Cap 'n' Collar and basic region leucine zipper (CNC-bZIP) family of transcription factors. It contains a Broad-complex, Tramtrack, and Bric-à-brac (BTB) domain, six cysteine-proline (CP) motifs, and a basic leucine zipper (bZIP) domain, which enable it to bind DNA and form heterodimers with small Maf proteins[1][2]. BACH1 primarily functions as a transcriptional repressor, regulating the expression of genes involved in oxidative stress response, heme homeostasis, cell cycle, and immunity. Dysregulation of BACH1 has been implicated in various diseases, including cancer, where it can promote tumor progression and metastasis by altering the expression of genes related to angiogenesis, epithelial-mesenchymal transition, and stemness. Additionally, BACH1 has been linked to neurodegenerative disorders and autoimmune diseases.
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技术参数
- 靶点基因名
- BACH1
- 蛋白别名
- BACH transcriptional regulator 1; BACH1
- UniProt
- O14867
- 物种
- Human
产品详情
- 靶点名称
- BACH1
- 蛋白名称
- BACH transcriptional regulator 1
- 蛋白别名
- Transcription regulator protein BACH1; BTB and CNC homolog 1; HA2303);BTB domain and CNC homolog 1
- 靶点基因名
- BACH1
- UniProt
- O14867
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transcription regulator protein BACH1 (BACH1) is a member of the Cap 'n' Collar and basic region leucine zipper (CNC-bZIP) family of transcription factors. It contains a Broad-complex, Tramtrack, and Bric-à-brac (BTB) domain, six cysteine-proline (CP) motifs, and a basic leucine zipper (bZIP) domain, which enable it to bind DNA and form heterodimers with small Maf proteins[1][2]. BACH1 primarily functions as a transcriptional repressor, regulating the expression of genes involved in oxidative stress response, heme homeostasis, cell cycle, and immunity. Dysregulation of BACH1 has been implicated in various diseases, including cancer, where it can promote tumor progression and metastasis by altering the expression of genes related to angiogenesis, epithelial-mesenchymal transition, and stemness. Additionally, BACH1 has been linked to neurodegenerative disorders and autoimmune diseases.