人 AXIN1 抗体对
01AB01921
Axin 1 (AXIN1) is a cytoplasmic scaffold protein that serves as a core component of the β-catenin destruction complex, providing essential negative regulation of the canonical Wnt signaling pathway. Through its RGS and DIX domains, AXIN1 coordinates interactions between APC, GSK3B, CSNK1, and DVL to promote the phosphorylation and proteasomal degradation of β-catenin. Beyond Wnt signaling, it participates in TGF-β signaling and forms complexes with HIPK2 and p53 to regulate cell growth and apoptosis. Somatic and germline alterations in AXIN1 are well-established drivers of various malignancies, including hepatocellular carcinoma, hepatoblastoma, and medulloblastoma, as well as developmental anomalies such as caudal duplication, primarily due to the loss of Wnt pathway control.
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技术参数
- 靶点基因名
- AXIN1
- 基因别名
- AXIN
- 蛋白别名
- axin 1; AXIN1
- UniProt
- O15169
- 物种
- Human
产品详情
- 靶点名称
- AXIN1
- 蛋白名称
- axin 1
- 蛋白别名
- Axin-1; Axis inhibition protein 1; hAxin
- 靶点基因名
- AXIN1
- 基因别名
- AXIN
- UniProt
- O15169
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Axin 1 (AXIN1) is a cytoplasmic scaffold protein that serves as a core component of the β-catenin destruction complex, providing essential negative regulation of the canonical Wnt signaling pathway. Through its RGS and DIX domains, AXIN1 coordinates interactions between APC, GSK3B, CSNK1, and DVL to promote the phosphorylation and proteasomal degradation of β-catenin. Beyond Wnt signaling, it participates in TGF-β signaling and forms complexes with HIPK2 and p53 to regulate cell growth and apoptosis. Somatic and germline alterations in AXIN1 are well-established drivers of various malignancies, including hepatocellular carcinoma, hepatoblastoma, and medulloblastoma, as well as developmental anomalies such as caudal duplication, primarily due to the loss of Wnt pathway control.