人 ATXN1 抗体对
01AB03943
Ataxin-1 (ATXN1) is a nuclear protein encoded by the ATXN1 gene, primarily known for its role in the regulation of gene expression and RNA processing. It contains an AXH domain, which facilitates interactions with other proteins, thereby influencing various cellular functions. ATXN1 is widely expressed in the brain and other tissues, where it participates in transcriptional regulation and may be involved in the assembly of protein complexes that modulate gene activity. The protein's structure allows it to engage in dynamic interactions within the nucleus, impacting cellular signaling pathways. Notably, mutations in the ATXN1 gene can lead to spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder characterized by motor coordination issues due to protein misfolding and aggregation.
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技术参数
- 靶点基因名
- ATXN1
- 基因别名
- ATX1; SCA1
- 蛋白别名
- ataxin 1; ATXN1
- UniProt
- P54253
- 物种
- Human
产品详情
- 靶点名称
- ATXN1
- 蛋白名称
- ataxin 1
- 蛋白别名
- Ataxin-1; Spinocerebellar ataxia type 1 protein
- 靶点基因名
- ATXN1
- 基因别名
- ATX1; SCA1
- UniProt
- P54253
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ataxin-1 (ATXN1) is a nuclear protein encoded by the ATXN1 gene, primarily known for its role in the regulation of gene expression and RNA processing. It contains an AXH domain, which facilitates interactions with other proteins, thereby influencing various cellular functions. ATXN1 is widely expressed in the brain and other tissues, where it participates in transcriptional regulation and may be involved in the assembly of protein complexes that modulate gene activity. The protein's structure allows it to engage in dynamic interactions within the nucleus, impacting cellular signaling pathways. Notably, mutations in the ATXN1 gene can lead to spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder characterized by motor coordination issues due to protein misfolding and aggregation.