人 ATP6V1G1 抗体对
01AB01919
ATPase H+ transporting V1 subunit G1 (ATP6V1G1) is a peripheral component of the cytosolic V1 sector of the vacuolar H+-ATPase (V-ATPase) complex. This multisubunit proton pump is responsible for the acidification of intracellular compartments, including endosomes, lysosomes, and secretory vesicles, by coupling ATP hydrolysis to proton translocation across membranes. Such acidification is vital for receptor-mediated endocytosis, protein sorting, and the activation of zymogens. ATP6V1G1 specifically contributes to the assembly and structural integrity of the V1 domain. Clinically, mutations in ATP6V1G1 are genetically linked to optic atrophy 6, a hereditary optic neuropathy, highlighting its essential role in maintaining the homeostasis of specialized neural tissues.
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技术参数
- 靶点基因名
- ATP6V1G1
- 基因别名
- ATP6G; ATP6G1; ATP6J
- 蛋白别名
- ATPase H+ transporting V1 subunit G1; ATP6V1G1
- UniProt
- O75348
- 物种
- Human
产品详情
- 靶点名称
- ATP6V1G1
- 蛋白名称
- ATPase H+ transporting V1 subunit G1
- 蛋白别名
- V-type proton ATPase subunit G 1; V-ATPase subunit G 1; V-ATPase 13 kDa subunit 1; Vacuolar proton pump subunit G 1; Vacuolar proton pump subunit M16
- 靶点基因名
- ATP6V1G1
- 基因别名
- ATP6G; ATP6G1; ATP6J
- UniProt
- O75348
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ATPase H+ transporting V1 subunit G1 (ATP6V1G1) is a peripheral component of the cytosolic V1 sector of the vacuolar H+-ATPase (V-ATPase) complex. This multisubunit proton pump is responsible for the acidification of intracellular compartments, including endosomes, lysosomes, and secretory vesicles, by coupling ATP hydrolysis to proton translocation across membranes. Such acidification is vital for receptor-mediated endocytosis, protein sorting, and the activation of zymogens. ATP6V1G1 specifically contributes to the assembly and structural integrity of the V1 domain. Clinically, mutations in ATP6V1G1 are genetically linked to optic atrophy 6, a hereditary optic neuropathy, highlighting its essential role in maintaining the homeostasis of specialized neural tissues.