人 ATP2B4 抗体对
01AB04234
ATPase plasma membrane Ca2+ transporting 4 (ATP2B4), is a protein encoded by the ATP2B4 gene. This enzyme belongs to the family of P-type primary ion transport ATPases and plays a critical role in intracellular calcium homeostasis by removing bivalent calcium ions from eukaryotic cells against large concentration gradients. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting functional adaptation to the physiological needs of particular cells and tissues. Diseases associated with ATP2B4 include Spastic Paraplegia 42, Autosomal Dominant, and it has been implicated in various other conditions such as familial adult myoclonic epilepsy, gastrointestinal stromal tumor, hypokalemic periodic paralysis, and parathyroid carcinoma. The protein is widely expressed in various tissues, including the brain, thyroid gland, parathyroid gland, and other organs.
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技术参数
- 靶点基因名
- ATP2B4
- 基因别名
- ATP2B2; MXRA1
- 蛋白别名
- ATPase plasma membrane Ca2+ transporting 4; ATP2B4
- UniProt
- P23634
- 物种
- Human
产品详情
- 靶点名称
- ATP2B4
- 蛋白名称
- ATPase plasma membrane Ca2+ transporting 4
- 蛋白别名
- Plasma membrane calcium-transporting ATPase 4; PMCA4; Matrix-remodeling-associated protein 1; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4
- 靶点基因名
- ATP2B4
- 基因别名
- ATP2B2; MXRA1
- UniProt
- P23634
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ATPase plasma membrane Ca2+ transporting 4 (ATP2B4), is a protein encoded by the ATP2B4 gene. This enzyme belongs to the family of P-type primary ion transport ATPases and plays a critical role in intracellular calcium homeostasis by removing bivalent calcium ions from eukaryotic cells against large concentration gradients. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting functional adaptation to the physiological needs of particular cells and tissues. Diseases associated with ATP2B4 include Spastic Paraplegia 42, Autosomal Dominant, and it has been implicated in various other conditions such as familial adult myoclonic epilepsy, gastrointestinal stromal tumor, hypokalemic periodic paralysis, and parathyroid carcinoma. The protein is widely expressed in various tissues, including the brain, thyroid gland, parathyroid gland, and other organs.