人 ATP1B4 抗体对
01AB01916
ATPase Na+/K+ transporting family member beta 4 (ATP1B4), a unique member of the Na+/K+-ATPase beta-subunit family, exhibits distinct structural and functional properties compared to its relatives. In lower vertebrates, it functions as a beta-subunit of the Na,K-ATPase ion pump at the plasma membrane, but in placental mammals, ATP1B4-encoded BetaM protein has evolved significantly. It lost its ancestral ion transport role and gained new properties as a muscle-specific protein localized to the inner nuclear membrane. This protein contains extended glutamate-rich clusters in its N-terminal domain and acts as a transcriptional coregulator during muscle development, especially in late fetal and early postnatal stages. ATP1B4's function in regulating gene expression through interaction with factors like SKIP is critical for perinatal development.
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技术参数
- 靶点基因名
- ATP1B4
- 蛋白别名
- ATPase Na+/K+ transporting family member beta 4; ATP1B4
- UniProt
- Q9UN42
- 物种
- Human
产品详情
- 靶点名称
- ATP1B4
- 蛋白名称
- ATPase Na+/K+ transporting family member beta 4
- 蛋白别名
- Protein ATP1B4; X; K-ATPase subunit beta-m; X/potassium-transporting ATPase subunit beta-m
- 靶点基因名
- ATP1B4
- UniProt
- Q9UN42
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ATPase Na+/K+ transporting family member beta 4 (ATP1B4), a unique member of the Na+/K+-ATPase beta-subunit family, exhibits distinct structural and functional properties compared to its relatives. In lower vertebrates, it functions as a beta-subunit of the Na,K-ATPase ion pump at the plasma membrane, but in placental mammals, ATP1B4-encoded BetaM protein has evolved significantly. It lost its ancestral ion transport role and gained new properties as a muscle-specific protein localized to the inner nuclear membrane. This protein contains extended glutamate-rich clusters in its N-terminal domain and acts as a transcriptional coregulator during muscle development, especially in late fetal and early postnatal stages. ATP1B4's function in regulating gene expression through interaction with factors like SKIP is critical for perinatal development.