抗人 ATG7 抗体对
01AB02791
Autophagy related 7 (ATG7) is an E1-like ubiquitin-like modifier-activating enzyme essential for macroautophagy and cytoplasm-to-vacuole transport. It activates ATG12 and ATG8/LC3 family proteins to drive ATG12-ATG5 conjugation and LC3 lipidation, which are critical steps for autophagosome membrane formation and cargo sequestration. Beyond its core role in autophagy, ATG7 modulates p53-dependent cell cycle pathways and participates in mitophagy, hematopoietic stem cell maintenance, and circadian control of metabolism. Pathogenic variants in ATG7 are established causes of autosomal recessive spinocerebellar ataxia 31, a neurodegenerative disorder characterized by Purkinje cell axonal dystrophy and impaired axonal autophagy.
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技术参数
- 靶点基因名
- ATG7
- 基因别名
- APG7L
- 蛋白别名
- autophagy related 7; ATG7
- UniProt
- O95352
- 物种
- Human
产品详情
- 靶点名称
- ATG7
- 蛋白名称
- autophagy related 7
- 蛋白别名
- Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like protein
- 靶点基因名
- ATG7
- 基因别名
- APG7L
- UniProt
- O95352
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Autophagy related 7 (ATG7) is an E1-like ubiquitin-like modifier-activating enzyme essential for macroautophagy and cytoplasm-to-vacuole transport. It activates ATG12 and ATG8/LC3 family proteins to drive ATG12-ATG5 conjugation and LC3 lipidation, which are critical steps for autophagosome membrane formation and cargo sequestration. Beyond its core role in autophagy, ATG7 modulates p53-dependent cell cycle pathways and participates in mitophagy, hematopoietic stem cell maintenance, and circadian control of metabolism. Pathogenic variants in ATG7 are established causes of autosomal recessive spinocerebellar ataxia 31, a neurodegenerative disorder characterized by Purkinje cell axonal dystrophy and impaired axonal autophagy.