人 ATF3 抗体对
01AB02592
Activating transcription factor 3 (ATF3) is a stress-inducible transcription factor of the ATF/CREB family that functions as a context-dependent transcriptional repressor or activator. It binds to cAMP response elements via a basic leucine zipper domain and is rapidly upregulated in response to diverse stressors, including endoplasmic reticulum stress, DNA damage, and oxidative stress. ATF3 acts as a central hub in adaptive responses, integrating inflammatory, apoptotic, and metabolic programs. Clinically, ATF3 is involved in the regulation of glucose and lipid metabolism and is implicated in metabolic syndrome, diabetes, and various cancers, where it can either suppress tumorigenesis or promote survival and progression depending on the signaling context.
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技术参数
- 靶点基因名
- ATF3
- 蛋白别名
- activating transcription factor 3; ATF3
- UniProt
- P18847
- 物种
- Human
产品详情
- 靶点名称
- ATF3
- 蛋白名称
- activating transcription factor 3
- 蛋白别名
- Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3
- 靶点基因名
- ATF3
- UniProt
- P18847
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Activating transcription factor 3 (ATF3) is a stress-inducible transcription factor of the ATF/CREB family that functions as a context-dependent transcriptional repressor or activator. It binds to cAMP response elements via a basic leucine zipper domain and is rapidly upregulated in response to diverse stressors, including endoplasmic reticulum stress, DNA damage, and oxidative stress. ATF3 acts as a central hub in adaptive responses, integrating inflammatory, apoptotic, and metabolic programs. Clinically, ATF3 is involved in the regulation of glucose and lipid metabolism and is implicated in metabolic syndrome, diabetes, and various cancers, where it can either suppress tumorigenesis or promote survival and progression depending on the signaling context.