抗人 ATF2 抗体对
01AB01022
Activating transcription factor 2 (ATF2) is a ubiquitously expressed member of the ATF/CREB family of transcription factors characterized by a bZIP-type DNA-binding domain, allowing it to form homodimers or heterodimers (notably with c-Jun) that bind to the cyclic AMP response element (CRE) in target gene promoters. ATF2 is primarily activated by stress-activated protein kinases such as JNK and p38, which phosphorylate it at threonine residues 69 and 71, enhancing its transcriptional activity and enabling regulation of genes involved in anti-apoptosis, cell growth, DNA damage response, and metabolic processes. The protein also possesses intrinsic histone acetylase activity, further promoting its DNA binding and transcriptional regulatory functions. In terms of disease relevance, ATF2 supports the antioxidant capacity of human mesenchymal stem cells and plays a role in cellular responses to stress and DNA damage, implicating it in conditions such as cancer, metabolic disorders, and inflammatory diseases.
| 规格 | 起售价 |
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技术参数
- 靶点基因名
- ATF2
- 基因别名
- CREB2; CREBP1
- 蛋白别名
- activating transcription factor 2; ATF2
- UniProt
- P15336
- 物种
- Human
产品详情
- 靶点名称
- ATF2
- 蛋白名称
- activating transcription factor 2
- 蛋白别名
- Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; cAMP response element-binding protein CRE-BP1
- 靶点基因名
- ATF2
- 基因别名
- CREB2; CREBP1
- UniProt
- P15336
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Activating transcription factor 2 (ATF2) is a ubiquitously expressed member of the ATF/CREB family of transcription factors characterized by a bZIP-type DNA-binding domain, allowing it to form homodimers or heterodimers (notably with c-Jun) that bind to the cyclic AMP response element (CRE) in target gene promoters. ATF2 is primarily activated by stress-activated protein kinases such as JNK and p38, which phosphorylate it at threonine residues 69 and 71, enhancing its transcriptional activity and enabling regulation of genes involved in anti-apoptosis, cell growth, DNA damage response, and metabolic processes. The protein also possesses intrinsic histone acetylase activity, further promoting its DNA binding and transcriptional regulatory functions. In terms of disease relevance, ATF2 supports the antioxidant capacity of human mesenchymal stem cells and plays a role in cellular responses to stress and DNA damage, implicating it in conditions such as cancer, metabolic disorders, and inflammatory diseases.