人 ASAP2 抗体对
01AB02125
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2) is a multidomain GTPase-activating protein that regulates the activity of Arf family proteins, including ARF1, ARF5, and ARF6. It localizes to the Golgi apparatus and plasma membrane, where it forms a stable complex with the kinase PYK2 and undergoes tyrosine phosphorylation by SRC. These interactions link ASAP2 to signaling-regulated vesicular transport, constitutive secretion, and FcγR-dependent phagocytosis. Furthermore, ASAP2 modulates cell migration by regulating the recruitment of paxillin to focal adhesions. Through its diverse domains, including PH, ankyrin repeats, and SH3, ASAP2 serves as a versatile scaffold that integrates membrane trafficking with cytoskeletal dynamics and intracellular signaling pathways.
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技术参数
- 靶点基因名
- ASAP2
- 基因别名
- DDEF2; KIAA0400
- 蛋白别名
- ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; ASAP2
- UniProt
- O43150
- 物种
- Human
产品详情
- 靶点名称
- ASAP2
- 蛋白名称
- ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- 蛋白别名
- Arf-GAP with SH3 domain; ANK repeat and PH domain-containing protein 2; Development and differentiation-enhancing factor 2; Paxillin-associated protein with ARF GAP activity 3; PAG3; Pyk2 C-terminus-associated protein; PAP
- 靶点基因名
- ASAP2
- 基因别名
- DDEF2; KIAA0400
- UniProt
- O43150
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2) is a multidomain GTPase-activating protein that regulates the activity of Arf family proteins, including ARF1, ARF5, and ARF6. It localizes to the Golgi apparatus and plasma membrane, where it forms a stable complex with the kinase PYK2 and undergoes tyrosine phosphorylation by SRC. These interactions link ASAP2 to signaling-regulated vesicular transport, constitutive secretion, and FcγR-dependent phagocytosis. Furthermore, ASAP2 modulates cell migration by regulating the recruitment of paxillin to focal adhesions. Through its diverse domains, including PH, ankyrin repeats, and SH3, ASAP2 serves as a versatile scaffold that integrates membrane trafficking with cytoskeletal dynamics and intracellular signaling pathways.