抗人 ASAH2 抗体对
01AB00645
Neutral ceramidase (ASAH2), encoded by the ASAH2 gene, is a type II integral membrane protein that plays a vital role in sphingolipid metabolism by hydrolyzing ceramide into sphingosine and free fatty acids. This enzymatic activity is crucial for regulating cellular levels of bioactive sphingolipids, which are involved in various signaling pathways related to cell growth and apoptosis. The protein exhibits optimal activity at a neutral pH (6.5-8.5) and is expressed predominantly in the brush border membranes of the intestine, as well as in other tissues like the kidney and brain. Dysregulation of ASAH2 has been implicated in several diseases, particularly in cancer; for instance, its inhibition has been linked to delayed tumor growth and increased ceramide levels in xenograft models. Additionally, ASAH2 is essential for the digestion of dietary sphingolipids in the intestine, and its deficiency can lead to impaired intestinal ceramide degradation, potentially affecting overall intestinal health and disease susceptibility.
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技术参数
- 靶点基因名
- ASAH2
- 基因别名
- HNAC1
- 蛋白别名
- N-acylsphingosine amidohydrolase 2; ASAH2
- UniProt
- Q9NR71
- 物种
- Human
产品详情
- 靶点名称
- ASAH2
- 蛋白名称
- N-acylsphingosine amidohydrolase 2
- 蛋白别名
- Neutral ceramidase; N-CDase; NCDase; Acylsphingosine deacylase 2; BCDase; LCDase; hCD; N-acylsphingosine amidohydrolase 2; Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form]
- 靶点基因名
- ASAH2
- 基因别名
- HNAC1
- UniProt
- Q9NR71
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Neutral ceramidase (ASAH2), encoded by the ASAH2 gene, is a type II integral membrane protein that plays a vital role in sphingolipid metabolism by hydrolyzing ceramide into sphingosine and free fatty acids. This enzymatic activity is crucial for regulating cellular levels of bioactive sphingolipids, which are involved in various signaling pathways related to cell growth and apoptosis. The protein exhibits optimal activity at a neutral pH (6.5-8.5) and is expressed predominantly in the brush border membranes of the intestine, as well as in other tissues like the kidney and brain. Dysregulation of ASAH2 has been implicated in several diseases, particularly in cancer; for instance, its inhibition has been linked to delayed tumor growth and increased ceramide levels in xenograft models. Additionally, ASAH2 is essential for the digestion of dietary sphingolipids in the intestine, and its deficiency can lead to impaired intestinal ceramide degradation, potentially affecting overall intestinal health and disease susceptibility.