人 ARTN 抗体对
01AB00453
Artemin (ARTN) is a neurotrophic factor belonging to the glial cell line-derived neurotrophic factor (GDNF) family of ligands. It plays a crucial role in the development and survival of neurons, particularly in the sympathetic nervous system and certain populations of central nervous system (CNS) neurons, including dopaminergic neurons. ARTN signals through the RET receptor tyrosine kinase and a glycosylphosphatidylinositol-anchored co-receptor GFRα3, promoting neuronal differentiation, survival, and growth. It acts as a chemoattractant, guiding sympathetic fibers along blood vessels to their target tissues. ARTN has potential therapeutic applications in neurodegenerative diseases due to its neuroprotective properties and ability to support neuronal survival and growth. Its expression in smooth muscle cells and along blood vessels underscores its role in guiding sympathetic axons during development.
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技术参数
- 靶点基因名
- ARTN
- 基因别名
- EVN
- 蛋白别名
- artemin; ARTN
- UniProt
- Q5T4W7
- 物种
- Human
产品详情
- 靶点名称
- ARTN
- 蛋白名称
- artemin
- 蛋白别名
- Artemin; Enovin; Neublastin
- 靶点基因名
- ARTN
- 基因别名
- EVN
- UniProt
- Q5T4W7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Artemin (ARTN) is a neurotrophic factor belonging to the glial cell line-derived neurotrophic factor (GDNF) family of ligands. It plays a crucial role in the development and survival of neurons, particularly in the sympathetic nervous system and certain populations of central nervous system (CNS) neurons, including dopaminergic neurons. ARTN signals through the RET receptor tyrosine kinase and a glycosylphosphatidylinositol-anchored co-receptor GFRα3, promoting neuronal differentiation, survival, and growth. It acts as a chemoattractant, guiding sympathetic fibers along blood vessels to their target tissues. ARTN has potential therapeutic applications in neurodegenerative diseases due to its neuroprotective properties and ability to support neuronal survival and growth. Its expression in smooth muscle cells and along blood vessels underscores its role in guiding sympathetic axons during development.