人 ARL16 抗体对
01AB01435
ARF like GTPase 16 (ARL16) is a small GTP-binding protein of the ARL family that regulates intracellular membrane trafficking and innate immune signaling. It localizes to intracellular membranes and plays a specialized role in Golgi-to-cilia transport, specifically mediating the export of IFT140 and INPP5E to support ciliary function. Additionally, ARL16 acts as a negative regulator of the antiviral response by binding to the C-terminal domain of RIG-I (DDX58) in a GTP-dependent manner, thereby suppressing RNA sensing activity. Although clinical data are emerging, genetic associations link ARL16 to Joubert syndrome 8 and childhood-onset schizophrenia, consistent with its roles in ciliary maintenance and neuronal processes.
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技术参数
- 靶点基因名
- ARL16
- 蛋白别名
- ARF like GTPase 16; ARL16
- UniProt
- Q0P5N6
- 物种
- Human
产品详情
- 靶点名称
- ARL16
- 蛋白名称
- ARF like GTPase 16
- 蛋白别名
- ADP-ribosylation factor-like protein 16
- 靶点基因名
- ARL16
- UniProt
- Q0P5N6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ARF like GTPase 16 (ARL16) is a small GTP-binding protein of the ARL family that regulates intracellular membrane trafficking and innate immune signaling. It localizes to intracellular membranes and plays a specialized role in Golgi-to-cilia transport, specifically mediating the export of IFT140 and INPP5E to support ciliary function. Additionally, ARL16 acts as a negative regulator of the antiviral response by binding to the C-terminal domain of RIG-I (DDX58) in a GTP-dependent manner, thereby suppressing RNA sensing activity. Although clinical data are emerging, genetic associations link ARL16 to Joubert syndrome 8 and childhood-onset schizophrenia, consistent with its roles in ciliary maintenance and neuronal processes.