抗人 ARHGAP1 抗体对
01AB00721
Rho GTPase activating protein 1 (ARHGAP1) is a member of the RhoGAP family that functions as a GTPase activator for Rho family proteins, including Rho, Rac, and Cdc42, with a preference for Cdc42. By stimulating the intrinsic GTPase activity of these small GTPases, ARHGAP1 converts them from their active GTP-bound state to an inactive GDP-bound state, thereby regulating cytoskeletal dynamics, cell migration, and various signaling pathways. ARHGAP1 is predominantly localized in the cytosol and interacts with multiple proteins through its SH3 domain, influencing processes such as actin filament organization and cell adhesion. In the context of disease, ARHGAP1 has been implicated in viral infections, notably influenza, where it is transported with the viral genome to stabilize actin filaments, facilitating the clustering of viral hemagglutinin (HA) at the plasma membrane. This process is crucial for the structural integrity and immune evasion of progeny viral particles.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- ARHGAP1
- 基因别名
- CDC42GAP; RHOGAP1
- 蛋白别名
- Rho GTPase activating protein 1; ARHGAP1
- UniProt
- Q07960
- 物种
- Human
产品详情
- 靶点名称
- ARHGAP1
- 蛋白名称
- Rho GTPase activating protein 1
- 蛋白别名
- Rho GTPase-activating protein 1; CDC42 GTPase-activating protein; GTPase-activating protein rhoGAP; Rho-related small GTPase protein activator; Rho-type GTPase-activating protein 1; p50-RhoGAP
- 靶点基因名
- ARHGAP1
- 基因别名
- CDC42GAP; RHOGAP1
- UniProt
- Q07960
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Rho GTPase activating protein 1 (ARHGAP1) is a member of the RhoGAP family that functions as a GTPase activator for Rho family proteins, including Rho, Rac, and Cdc42, with a preference for Cdc42. By stimulating the intrinsic GTPase activity of these small GTPases, ARHGAP1 converts them from their active GTP-bound state to an inactive GDP-bound state, thereby regulating cytoskeletal dynamics, cell migration, and various signaling pathways. ARHGAP1 is predominantly localized in the cytosol and interacts with multiple proteins through its SH3 domain, influencing processes such as actin filament organization and cell adhesion. In the context of disease, ARHGAP1 has been implicated in viral infections, notably influenza, where it is transported with the viral genome to stabilize actin filaments, facilitating the clustering of viral hemagglutinin (HA) at the plasma membrane. This process is crucial for the structural integrity and immune evasion of progeny viral particles.