人 ARFGAP2 抗体对
01AB03080
ARF GTPase activating protein 2 (ARFGAP2) is a cytosolic and Golgi-associated protein that functions as a GTPase-activating protein (GAP) for ARF1. By stimulating ARF1 GTP hydrolysis, it regulates COPI-mediated retrograde vesicular trafficking from the Golgi complex to the endoplasmic reticulum. ARFGAP2 is recruited to Golgi membranes via direct interaction with coatomer proteins rather than lipids. While its primary role is in intracellular transport, genetic studies have noted associations between ARFGAP2 and conditions such as combined oxidative phosphorylation deficiency and retinal disease, likely reflecting the downstream consequences of trafficking defects.
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技术参数
- 靶点基因名
- ARFGAP2
- 基因别名
- ZNF289
- 蛋白别名
- ARF GTPase activating protein 2; ARFGAP2
- UniProt
- Q8N6H7
- 物种
- Human
产品详情
- 靶点名称
- ARFGAP2
- 蛋白名称
- ARF GTPase activating protein 2
- 蛋白别名
- ADP-ribosylation factor GTPase-activating protein 2; ARF GAP 2; GTPase-activating protein ZNF289; Zinc finger protein 289
- 靶点基因名
- ARFGAP2
- 基因别名
- ZNF289
- UniProt
- Q8N6H7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ARF GTPase activating protein 2 (ARFGAP2) is a cytosolic and Golgi-associated protein that functions as a GTPase-activating protein (GAP) for ARF1. By stimulating ARF1 GTP hydrolysis, it regulates COPI-mediated retrograde vesicular trafficking from the Golgi complex to the endoplasmic reticulum. ARFGAP2 is recruited to Golgi membranes via direct interaction with coatomer proteins rather than lipids. While its primary role is in intracellular transport, genetic studies have noted associations between ARFGAP2 and conditions such as combined oxidative phosphorylation deficiency and retinal disease, likely reflecting the downstream consequences of trafficking defects.