人 APOC3 抗体对
01AB01148
Apolipoprotein C-III (APOC3) is a protein that plays a key role in triglyceride metabolism and cardiovascular disease risk. Studies have shown that loss-of-function mutations in the APOC3 gene are associated with lower triglyceride levels and a reduced risk of ischemic cardiovascular disease and coronary heart disease. The mechanism by which APOC3 influences cardiovascular disease risk is multifaceted. APOC3 inhibits lipoprotein lipase and hepatic lipase, which are enzymes involved in the clearance of triglyceride-rich lipoproteins. This leads to increased triglyceride levels, which is a well-established risk factor for cardiovascular disease. Additionally, APOC3 has been found to directly promote atherosclerosis by localizing to atherosclerotic lesions and inducing inflammatory and calcification pathways. Elevated APOC3 levels have also been linked to impaired pancreatic beta-cell function and the development of type 2 diabetes.
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技术参数
- 靶点基因名
- APOC3
- 蛋白别名
- apolipoprotein C3; APOC3
- UniProt
- P02656
- 物种
- Human
产品详情
- 靶点名称
- APOC3
- 蛋白名称
- apolipoprotein C3
- 蛋白别名
- Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3
- 靶点基因名
- APOC3
- UniProt
- P02656
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Apolipoprotein C-III (APOC3) is a protein that plays a key role in triglyceride metabolism and cardiovascular disease risk. Studies have shown that loss-of-function mutations in the APOC3 gene are associated with lower triglyceride levels and a reduced risk of ischemic cardiovascular disease and coronary heart disease. The mechanism by which APOC3 influences cardiovascular disease risk is multifaceted. APOC3 inhibits lipoprotein lipase and hepatic lipase, which are enzymes involved in the clearance of triglyceride-rich lipoproteins. This leads to increased triglyceride levels, which is a well-established risk factor for cardiovascular disease. Additionally, APOC3 has been found to directly promote atherosclerosis by localizing to atherosclerotic lesions and inducing inflammatory and calcification pathways. Elevated APOC3 levels have also been linked to impaired pancreatic beta-cell function and the development of type 2 diabetes.