人 ApoA4 抗体对
01AB04221
Apolipoprotein A4 (APOA4) is a crucial lipid-binding protein primarily synthesized in the small intestine, where it plays a significant role in lipid metabolism and absorption. The protein, consisting of 376 amino acids, is secreted into circulation on chylomicrons and high-density lipoproteins (HDL), contributing to the regulation of lipid transport and metabolism. APOA4 is known to activate lecithin-cholesterol acyltransferase (LCAT) and modulate appetite and satiety, indicating its involvement in energy homeostasis. In terms of disease associations, APOA4 deficiency has been linked to metabolic disorders such as atherosclerosis and diabetes. Additionally, variations in the APOA4 gene have been implicated in familial hyperlipidemia. The protein exhibits antioxidant properties and may protect against atherosclerosis by influencing cholesterol metabolism and reducing inflammation.
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技术参数
- 靶点基因名
- APOA4
- 蛋白别名
- apolipoprotein A4; ApoA4
- UniProt
- P06727
- 物种
- Human
产品详情
- 靶点名称
- ApoA4
- 蛋白名称
- apolipoprotein A4
- 蛋白别名
- Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4
- 靶点基因名
- APOA4
- UniProt
- P06727
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Apolipoprotein A4 (APOA4) is a crucial lipid-binding protein primarily synthesized in the small intestine, where it plays a significant role in lipid metabolism and absorption. The protein, consisting of 376 amino acids, is secreted into circulation on chylomicrons and high-density lipoproteins (HDL), contributing to the regulation of lipid transport and metabolism. APOA4 is known to activate lecithin-cholesterol acyltransferase (LCAT) and modulate appetite and satiety, indicating its involvement in energy homeostasis. In terms of disease associations, APOA4 deficiency has been linked to metabolic disorders such as atherosclerosis and diabetes. Additionally, variations in the APOA4 gene have been implicated in familial hyperlipidemia. The protein exhibits antioxidant properties and may protect against atherosclerosis by influencing cholesterol metabolism and reducing inflammation.