抗人 APEX2 抗体对
01AB03940
Apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2) is a highly reactive enzyme that plays a crucial role in cellular processes, particularly in DNA repair and RNA regulation. It catalyzes the cleavage of apurinic/apyrimidinic sites in DNA, which are critical for maintaining genomic integrity. APEX2 has been extensively utilized in proximity labeling techniques to map protein interactions and cellular dynamics, revealing its involvement in various biological pathways and disease states. For instance, studies have demonstrated that APEX2 can identify proteins associated with stress granules, implicating its role in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) by uncovering aberrant protein interactions in affected neurons. Additionally, APEX2's application in studying viral proteins has provided insights into host-pathogen interactions, highlighting its significance in understanding viral replication mechanisms.
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技术参数
- 靶点基因名
- APEX2
- 基因别名
- APE2; APEXL2; XTH2
- 蛋白别名
- apurinic/apyrimidinic endodeoxyribonuclease 2; APEX2
- UniProt
- Q9UBZ4
- 物种
- Human
产品详情
- 靶点名称
- APEX2
- 蛋白名称
- apurinic/apyrimidinic endodeoxyribonuclease 2
- 蛋白别名
- DNA-(apurinic or apyrimidinic site) endonuclease 2; AP endonuclease XTH2; APEX nuclease 2; APEX nuclease-like 2; Apurinic-apyrimidinic endonuclease 2; AP endonuclease 2
- 靶点基因名
- APEX2
- 基因别名
- APE2; APEXL2; XTH2
- UniProt
- Q9UBZ4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2) is a highly reactive enzyme that plays a crucial role in cellular processes, particularly in DNA repair and RNA regulation. It catalyzes the cleavage of apurinic/apyrimidinic sites in DNA, which are critical for maintaining genomic integrity. APEX2 has been extensively utilized in proximity labeling techniques to map protein interactions and cellular dynamics, revealing its involvement in various biological pathways and disease states. For instance, studies have demonstrated that APEX2 can identify proteins associated with stress granules, implicating its role in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) by uncovering aberrant protein interactions in affected neurons. Additionally, APEX2's application in studying viral proteins has provided insights into host-pathogen interactions, highlighting its significance in understanding viral replication mechanisms.