抗人 APEX1 抗体对
01AB03936
DNA repair nuclease/redox regulator APEX1 (APEX1) is a multifunctional enzyme that plays a crucial role in the repair of damaged DNA and the regulation of cellular redox states. It primarily functions as an apurinic/apyrimidinic (AP) endonuclease, recognizing and incising abasic sites in DNA, which are common lesions resulting from oxidative damage or spontaneous hydrolysis. APEX1 is involved in the base excision repair (BER) pathway, initiating the repair process by cleaving the phosphodiester backbone adjacent to AP sites. Dysregulation or mutations in APEX1 have been linked to various diseases, including cancer and neurodegenerative disorders, where impaired DNA repair mechanisms contribute to genomic instability. Additionally, APEX1's redox regulatory functions influence the activity of transcription factors involved in stress responses and cell survival.
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技术参数
- 靶点基因名
- APEX1
- 基因别名
- APE; APE1; APEX; APX; HAP1; REF1
- 蛋白别名
- apurinic/apyrimidinic endodeoxyribonuclease 1; APEX1
- UniProt
- P27695
- 物种
- Human
产品详情
- 靶点名称
- APEX1
- 蛋白名称
- apurinic/apyrimidinic endodeoxyribonuclease 1
- 蛋白别名
- DNA-(apurinic or apyrimidinic site) endonuclease; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) endonuclease; mitochondrial]
- 靶点基因名
- APEX1
- 基因别名
- APE; APE1; APEX; APX; HAP1; REF1
- UniProt
- P27695
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
DNA repair nuclease/redox regulator APEX1 (APEX1) is a multifunctional enzyme that plays a crucial role in the repair of damaged DNA and the regulation of cellular redox states. It primarily functions as an apurinic/apyrimidinic (AP) endonuclease, recognizing and incising abasic sites in DNA, which are common lesions resulting from oxidative damage or spontaneous hydrolysis. APEX1 is involved in the base excision repair (BER) pathway, initiating the repair process by cleaving the phosphodiester backbone adjacent to AP sites. Dysregulation or mutations in APEX1 have been linked to various diseases, including cancer and neurodegenerative disorders, where impaired DNA repair mechanisms contribute to genomic instability. Additionally, APEX1's redox regulatory functions influence the activity of transcription factors involved in stress responses and cell survival.