人 APC6 抗体对
01AB00481
Cell Division Cycle 16 (CDC16) is a protein encoded by the CDC16 gene in humans. It functions as a component of the anaphase-promoting complex (APC), a multiprotein E3 ubiquitin ligase that governs exit from mitosis by targeting cell cycle proteins for degradation by the 26S proteasome. The APC complex is crucial for the regulation of mitotic nuclear division and contains a tetratricopeptide repeat (TPR) domain, which is involved in protein-protein interactions. CDC16 has been shown to interact with CDC27 and CDC20, and its dysregulation has been associated with diseases such as Deafness, Autosomal Dominant 65, and Developmental And Epileptic Encephalopathy 16. The protein is highly conserved among eukaryotic organisms and plays a critical role in the cell cycle, particularly in the transition from mitosis to the G1 phase.
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技术参数
- 靶点基因名
- CDC16
- 基因别名
- ANAPC6
- 蛋白别名
- cell division cycle 16; APC6
- UniProt
- Q13042
- 物种
- Human
产品详情
- 靶点名称
- APC6
- 蛋白名称
- cell division cycle 16
- 蛋白别名
- Cell division cycle protein 16 homolog; Anaphase-promoting complex subunit 6; APC6; CDC16 homolog; CDC16Hs; Cyclosome subunit 6
- 靶点基因名
- CDC16
- 基因别名
- ANAPC6
- UniProt
- Q13042
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cell Division Cycle 16 (CDC16) is a protein encoded by the CDC16 gene in humans. It functions as a component of the anaphase-promoting complex (APC), a multiprotein E3 ubiquitin ligase that governs exit from mitosis by targeting cell cycle proteins for degradation by the 26S proteasome. The APC complex is crucial for the regulation of mitotic nuclear division and contains a tetratricopeptide repeat (TPR) domain, which is involved in protein-protein interactions. CDC16 has been shown to interact with CDC27 and CDC20, and its dysregulation has been associated with diseases such as Deafness, Autosomal Dominant 65, and Developmental And Epileptic Encephalopathy 16. The protein is highly conserved among eukaryotic organisms and plays a critical role in the cell cycle, particularly in the transition from mitosis to the G1 phase.