人 ANXA11 抗体对
01AB04220
Annexin A11 (ANXA11) is a calcium-dependent phospholipid-binding protein belonging to the annexin family, implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Structurally, ANXA11 contains a conserved calcium-binding C-terminal domain common to all annexins and a putative intrinsically unfolded N-terminal region specific to ANXA11. Mutations in ANXA11 have been linked to ALS. The protein's core domain is formed by four helical repeats and binds to phospholipids in a calcium-dependent manner, influencing membrane properties such as curvature and phase separation. The N-terminal region also interacts with other proteins like ALG-2 and S100A6, suggesting a multifunctional role of ANXA11 in cellular processes.
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技术参数
- 靶点基因名
- ANXA11
- 基因别名
- ANX11
- 蛋白别名
- annexin A11; ANXA11
- UniProt
- P50995
- 物种
- Human
产品详情
- 靶点名称
- ANXA11
- 蛋白名称
- annexin A11
- 蛋白别名
- Annexin A11; 56 kDa autoantigen; Annexin XI; Annexin-11; Calcyclin-associated annexin 50; CAP-50
- 靶点基因名
- ANXA11
- 基因别名
- ANX11
- UniProt
- P50995
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Annexin A11 (ANXA11) is a calcium-dependent phospholipid-binding protein belonging to the annexin family, implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Structurally, ANXA11 contains a conserved calcium-binding C-terminal domain common to all annexins and a putative intrinsically unfolded N-terminal region specific to ANXA11. Mutations in ANXA11 have been linked to ALS. The protein's core domain is formed by four helical repeats and binds to phospholipids in a calcium-dependent manner, influencing membrane properties such as curvature and phase separation. The N-terminal region also interacts with other proteins like ALG-2 and S100A6, suggesting a multifunctional role of ANXA11 in cellular processes.