人 ANXA1 抗体对
01AB04216
Annexin A1 (ANXA1) is a 37-kDa calcium-dependent phospholipid-binding protein that plays a crucial role in mediating anti-inflammatory responses and regulating immune functions. Primarily recognized for its ability to inhibit phospholipase A2, ANXA1 prevents the release of arachidonic acid, thereby blocking the synthesis of pro-inflammatory eicosanoids such as prostaglandins and leukotrienes. This protein interacts with G-protein coupled receptors, particularly formyl peptide receptor 2 (FPR2), to exert its effects on leukocyte behavior, including inhibiting their migration and promoting apoptosis. ANXA1's involvement in various diseases is significant; it has been linked to conditions characterized by inflammation, such as diabetes, cardiovascular diseases, and neurodegenerative disorders. Its expression is crucial for maintaining blood-brain barrier integrity and modulating the inflammatory response in ocular diseases like uveitis.
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技术参数
- 靶点基因名
- ANXA1
- 基因别名
- ANX1; LPC1
- 蛋白别名
- annexin A1; ANXA1
- UniProt
- P04083
- 物种
- Human
产品详情
- 靶点名称
- ANXA1
- 蛋白名称
- annexin A1
- 蛋白别名
- Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35) [Cleaved into: Annexin Ac2-26]
- 靶点基因名
- ANXA1
- 基因别名
- ANX1; LPC1
- UniProt
- P04083
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Annexin A1 (ANXA1) is a 37-kDa calcium-dependent phospholipid-binding protein that plays a crucial role in mediating anti-inflammatory responses and regulating immune functions. Primarily recognized for its ability to inhibit phospholipase A2, ANXA1 prevents the release of arachidonic acid, thereby blocking the synthesis of pro-inflammatory eicosanoids such as prostaglandins and leukotrienes. This protein interacts with G-protein coupled receptors, particularly formyl peptide receptor 2 (FPR2), to exert its effects on leukocyte behavior, including inhibiting their migration and promoting apoptosis. ANXA1's involvement in various diseases is significant; it has been linked to conditions characterized by inflammation, such as diabetes, cardiovascular diseases, and neurodegenerative disorders. Its expression is crucial for maintaining blood-brain barrier integrity and modulating the inflammatory response in ocular diseases like uveitis.