抗人 ANGPTL2 抗体对
01AB00718
Angiopoietin like 2 (ANGPTL2) is a secreted glycoprotein belonging to the angiopoietin-like family. It contains an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain. ANGPTL2 is widely expressed in various tissues and plays roles in angiogenesis, tissue repair, and hematopoietic stem cell survival. It functions through autocrine and paracrine mechanisms, promoting endothelial cell sprouting and migration. ANGPTL2 also enhances the expansion of hematopoietic stem cells. The protein's receptor has been identified as LILRB2, with both domains required for optimal binding. In pathological conditions, elevated ANGPTL2 levels are associated with chronic inflammation, obesity, and insulin resistance. It contributes to the development of metabolic diseases, atherosclerosis, and various cancers. ANGPTL2 has been implicated in promoting tumor progression and metastasis, making it a potential biomarker and therapeutic target for multiple chronic diseases.
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技术参数
- 靶点基因名
- ANGPTL2
- 基因别名
- ARP2
- 蛋白别名
- angiopoietin like 2; ANGPTL2
- UniProt
- Q9UKU9
- 物种
- Human
产品详情
- 靶点名称
- ANGPTL2
- 蛋白名称
- angiopoietin like 2
- 蛋白别名
- Angiopoietin-related protein 2; Angiopoietin-like protein 2
- 靶点基因名
- ANGPTL2
- 基因别名
- ARP2
- UniProt
- Q9UKU9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Angiopoietin like 2 (ANGPTL2) is a secreted glycoprotein belonging to the angiopoietin-like family. It contains an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain. ANGPTL2 is widely expressed in various tissues and plays roles in angiogenesis, tissue repair, and hematopoietic stem cell survival. It functions through autocrine and paracrine mechanisms, promoting endothelial cell sprouting and migration. ANGPTL2 also enhances the expansion of hematopoietic stem cells. The protein's receptor has been identified as LILRB2, with both domains required for optimal binding. In pathological conditions, elevated ANGPTL2 levels are associated with chronic inflammation, obesity, and insulin resistance. It contributes to the development of metabolic diseases, atherosclerosis, and various cancers. ANGPTL2 has been implicated in promoting tumor progression and metastasis, making it a potential biomarker and therapeutic target for multiple chronic diseases.