抗人 ANGPTL1 抗体对
01AB02786
Angiopoietin-like 1 (ANGPTL1), also known as angioarrestin, is a secreted glycoprotein belonging to the angiopoietin-like family. Characterized by an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, ANGPTL1 does not function as a classical endothelial mitogen but acts as a potent anti-angiogenic and vascular-stabilizing factor. It inhibits VEGF and bFGF-induced endothelial cell proliferation, migration, and permeability while exerting anti-apoptotic effects via ERK and AKT signaling. Widely expressed in vascularized tissues such as the liver and thyroid, ANGPTL1 functions as a tumor suppressor. Its overexpression is correlated with reduced tumor growth and metastasis in hepatocellular carcinoma and breast cancer, mediated in part by the suppression of epithelial-to-mesenchymal transition.
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技术参数
- 靶点基因名
- ANGPTL1
- 基因别名
- ANG3; ANGPT3; ARP1
- 蛋白别名
- angiopoietin like 1; ANGPTL1
- UniProt
- O95841
- 物种
- Human
产品详情
- 靶点名称
- ANGPTL1
- 蛋白名称
- angiopoietin like 1
- 蛋白别名
- Angiopoietin-related protein 1; Angiopoietin-3; ANG-3; Angiopoietin-like protein 1
- 靶点基因名
- ANGPTL1
- 基因别名
- ANG3; ANGPT3; ARP1
- UniProt
- O95841
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Angiopoietin-like 1 (ANGPTL1), also known as angioarrestin, is a secreted glycoprotein belonging to the angiopoietin-like family. Characterized by an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, ANGPTL1 does not function as a classical endothelial mitogen but acts as a potent anti-angiogenic and vascular-stabilizing factor. It inhibits VEGF and bFGF-induced endothelial cell proliferation, migration, and permeability while exerting anti-apoptotic effects via ERK and AKT signaling. Widely expressed in vascularized tissues such as the liver and thyroid, ANGPTL1 functions as a tumor suppressor. Its overexpression is correlated with reduced tumor growth and metastasis in hepatocellular carcinoma and breast cancer, mediated in part by the suppression of epithelial-to-mesenchymal transition.