人 Angiopoietin-2 抗体对
01AB02524
Angiopoietin-2 (ANGPT2) is a protein encoded by the ANGPT2 gene in humans. It is a naturally occurring antagonist for both ANGPT1 and the endothelial cell-specific receptor tyrosine kinase TIE2. ANGPT2 is primarily expressed by endothelial cells at sites of vascular remodeling and attenuates vascular stability by counteracting the effects of ANGPT1, and is involved in various physiological and pathological processes, including tumor growth and cardiovascular diseases. Elevated levels of ANGPT2 have been associated with several diseases, particularly in conditions like cancer, where it contributes to tumor angiogenesis and metastasis, and in cardiovascular disorders, where it may indicate endothelial dysfunction.
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技术参数
- 靶点基因名
- ANGPT2
- 蛋白别名
- angiopoietin 2; Angiopoietin-2
- UniProt
- O15123
- 物种
- Human
产品详情
- 靶点名称
- Angiopoietin-2
- 蛋白名称
- angiopoietin 2
- 蛋白别名
- Angiopoietin-2; ANG-2
- 靶点基因名
- ANGPT2
- UniProt
- O15123
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Angiopoietin-2 (ANGPT2) is a protein encoded by the ANGPT2 gene in humans. It is a naturally occurring antagonist for both ANGPT1 and the endothelial cell-specific receptor tyrosine kinase TIE2. ANGPT2 is primarily expressed by endothelial cells at sites of vascular remodeling and attenuates vascular stability by counteracting the effects of ANGPT1, and is involved in various physiological and pathological processes, including tumor growth and cardiovascular diseases. Elevated levels of ANGPT2 have been associated with several diseases, particularly in conditions like cancer, where it contributes to tumor angiogenesis and metastasis, and in cardiovascular disorders, where it may indicate endothelial dysfunction.