抗人 ANAPC7 抗体对
01AB02782
Anaphase promoting complex subunit 7 (ANAPC7) is a tetratricopeptide repeat-containing protein that serves as a core component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase essential for cell cycle regulation, particularly the transition through mitosis and G1 phase by targeting key cell cycle regulators such as B-type cyclins for ubiquitin-mediated proteasomal degradation. ANAPC7 is required for the proper ubiquitination activity of the APC/C and facilitates its interaction with specific transcription coactivators, contributing to the precise timing of cell cycle events. The protein interacts with other APC/C subunits, including ANAPC1, ANAPC4, CDC27, and CDC20, and is expressed in various tissues, reflecting its fundamental role in cell division. Disruption or dysregulation of ANAPC7 or the APC/C complex has been implicated in aberrant cell cycle progression, which may contribute to tumorigenesis and cancer development.
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技术参数
- 靶点基因名
- ANAPC7
- 基因别名
- APC7
- 蛋白别名
- anaphase promoting complex subunit 7; ANAPC7
- UniProt
- Q9UJX3
- 物种
- Human
产品详情
- 靶点名称
- ANAPC7
- 蛋白名称
- anaphase promoting complex subunit 7
- 蛋白别名
- Anaphase-promoting complex subunit 7; APC7; Cyclosome subunit 7
- 靶点基因名
- ANAPC7
- 基因别名
- APC7
- UniProt
- Q9UJX3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Anaphase promoting complex subunit 7 (ANAPC7) is a tetratricopeptide repeat-containing protein that serves as a core component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase essential for cell cycle regulation, particularly the transition through mitosis and G1 phase by targeting key cell cycle regulators such as B-type cyclins for ubiquitin-mediated proteasomal degradation. ANAPC7 is required for the proper ubiquitination activity of the APC/C and facilitates its interaction with specific transcription coactivators, contributing to the precise timing of cell cycle events. The protein interacts with other APC/C subunits, including ANAPC1, ANAPC4, CDC27, and CDC20, and is expressed in various tissues, reflecting its fundamental role in cell division. Disruption or dysregulation of ANAPC7 or the APC/C complex has been implicated in aberrant cell cycle progression, which may contribute to tumorigenesis and cancer development.