抗人 ANAPC10 抗体对
01AB03322
Anaphase promoting complex subunit 10 (ANAPC10) is a core component of the anaphase-promoting complex/cyclosome (APC/C), a large cell cycle-regulated E3 ubiquitin ligase. It plays a critical role in substrate recognition and promotes processive ubiquitination, facilitating the formation of Lys11-linked and Lys11/Lys48-branched polyubiquitin chains on key cell cycle regulators such as securin and cyclin B. These modifications are essential for sister chromatid separation and mitotic exit. By ensuring the timely degradation of its targets, ANAPC10 maintains the fidelity of mitosis and G1 progression across various tissues, including the testis and thyroid.
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技术参数
- 靶点基因名
- ANAPC10
- 基因别名
- APC10
- 蛋白别名
- anaphase promoting complex subunit 10; ANAPC10
- UniProt
- Q9UM13
- 物种
- Human
产品详情
- 靶点名称
- ANAPC10
- 蛋白名称
- anaphase promoting complex subunit 10
- 蛋白别名
- Anaphase-promoting complex subunit 10; APC10; Cyclosome subunit 10
- 靶点基因名
- ANAPC10
- 基因别名
- APC10
- UniProt
- Q9UM13
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Anaphase promoting complex subunit 10 (ANAPC10) is a core component of the anaphase-promoting complex/cyclosome (APC/C), a large cell cycle-regulated E3 ubiquitin ligase. It plays a critical role in substrate recognition and promotes processive ubiquitination, facilitating the formation of Lys11-linked and Lys11/Lys48-branched polyubiquitin chains on key cell cycle regulators such as securin and cyclin B. These modifications are essential for sister chromatid separation and mitotic exit. By ensuring the timely degradation of its targets, ANAPC10 maintains the fidelity of mitosis and G1 progression across various tissues, including the testis and thyroid.