抗人 AMN 抗体对
01AB01011
Amnion associated transmembrane protein (AMN) is a type I transmembrane protein primarily found embedded in the outer membrane of kidney cells and cells lining the small intestine. It functions by binding to cubilin, anchoring it to the cell membrane, and is essential for vitamin B12 uptake from food. AMN helps transfer the cubilin-vitamin B12 complex into intestinal cells, from where the vitamin is released into the bloodstream. In the kidneys, AMN and cubilin participate in reabsorbing certain proteins that would otherwise be excreted in urine. Additionally, AMN is thought to modulate bone morphogenetic protein (BMP) receptor function. Mutations in the AMN gene can lead to hereditary megaloblastic anemia, a condition characterized by abnormally large red blood cells and neurological complications due to impaired vitamin B12 absorption, which affects DNA formation, protein production, cellular energy generation, and fat metabolism.
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技术参数
- 靶点基因名
- AMN
- 蛋白别名
- amnion associated transmembrane protein; AMN
- UniProt
- Q9BXJ7
- 物种
- Human
产品详情
- 靶点名称
- AMN
- 蛋白名称
- amnion associated transmembrane protein
- 蛋白别名
- Protein amnionless [Cleaved into: Soluble protein amnionless]
- 靶点基因名
- AMN
- UniProt
- Q9BXJ7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Amnion associated transmembrane protein (AMN) is a type I transmembrane protein primarily found embedded in the outer membrane of kidney cells and cells lining the small intestine. It functions by binding to cubilin, anchoring it to the cell membrane, and is essential for vitamin B12 uptake from food. AMN helps transfer the cubilin-vitamin B12 complex into intestinal cells, from where the vitamin is released into the bloodstream. In the kidneys, AMN and cubilin participate in reabsorbing certain proteins that would otherwise be excreted in urine. Additionally, AMN is thought to modulate bone morphogenetic protein (BMP) receptor function. Mutations in the AMN gene can lead to hereditary megaloblastic anemia, a condition characterized by abnormally large red blood cells and neurological complications due to impaired vitamin B12 absorption, which affects DNA formation, protein production, cellular energy generation, and fat metabolism.