人αA Crystallin 抗体对
01AB00194
Crystallin alpha A (CRYAA) is a protein encoded by the CRYAA gene in humans, primarily found in the vertebrate eye lens. It belongs to the small heat-shock protein family and plays a crucial role in maintaining the transparency and refractive index of the lens. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, with alpha-A being preferentially restricted to the lens and alpha-B expressed widely in many tissues and organs. The protein acts as a molecular chaperone, holding proteins in large soluble aggregates rather than renaturing them, and its post-translational modifications can decrease its chaperone activity. The alpha-A and alpha-B subunits form heterogeneous aggregates with a 3:1 ratio, respectively, and are involved in the intracellular architecture and autokinase activity. Defects in the CRYAA gene can cause autosomal dominant congenital cataract (ADCC), a condition characterized by lens opacity at birth.
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技术参数
- 靶点基因名
- CRYAA
- 基因别名
- CRYA1; HSPB4
- 蛋白别名
- crystallin alpha A; alpha A Crystallin
- UniProt
- P02489
- 物种
- Human
产品详情
- 靶点名称
- alpha A Crystallin
- 蛋白名称
- crystallin alpha A
- 蛋白别名
- Alpha-crystallin A chain; Heat shock protein beta-4; HspB4) [Cleaved into: Alpha-crystallin A(1-172; Alpha-crystallin A(1-168; Alpha-crystallin A(1-162]
- 靶点基因名
- CRYAA
- 基因别名
- CRYA1; HSPB4
- UniProt
- P02489
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Crystallin alpha A (CRYAA) is a protein encoded by the CRYAA gene in humans, primarily found in the vertebrate eye lens. It belongs to the small heat-shock protein family and plays a crucial role in maintaining the transparency and refractive index of the lens. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, with alpha-A being preferentially restricted to the lens and alpha-B expressed widely in many tissues and organs. The protein acts as a molecular chaperone, holding proteins in large soluble aggregates rather than renaturing them, and its post-translational modifications can decrease its chaperone activity. The alpha-A and alpha-B subunits form heterogeneous aggregates with a 3:1 ratio, respectively, and are involved in the intracellular architecture and autokinase activity. Defects in the CRYAA gene can cause autosomal dominant congenital cataract (ADCC), a condition characterized by lens opacity at birth.