人 ALDH1B1 抗体对
01AB02122
Aldehyde dehydrogenase 1 family member B1 (ALDH1B1) is a mitochondrial NAD-dependent oxidoreductase that plays a critical role in the major oxidative pathway of ethanol metabolism. It catalyzes the irreversible oxidation of various aldehydes, most notably acetaldehyde, into their corresponding carboxylic acids, thereby contributing to cellular detoxification and redox homeostasis. As a key enzyme in phase I and II biotransformation, ALDH1B1 is involved in broader metabolic and protein metabolism pathways. Genetic variations in the ALDH1B1 locus are associated with interindividual susceptibility to alcohol-related disorders. Clinically, the role of ALDH1B1 in acetaldehyde detoxification suggests its relevance to alcohol-induced organ damage and carcinogenesis, as well as potential links to mitochondrial diseases and certain forms of epilepsy.
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技术参数
- 靶点基因名
- ALDH1B1
- 基因别名
- ALDH5; ALDHX
- 蛋白别名
- aldehyde dehydrogenase 1 family member B1; ALDH1B1
- UniProt
- P30837
- 物种
- Human
产品详情
- 靶点名称
- ALDH1B1
- 蛋白名称
- aldehyde dehydrogenase 1 family member B1
- 蛋白别名
- Aldehyde dehydrogenase X; mitochondrial; Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1
- 靶点基因名
- ALDH1B1
- 基因别名
- ALDH5; ALDHX
- UniProt
- P30837
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Aldehyde dehydrogenase 1 family member B1 (ALDH1B1) is a mitochondrial NAD-dependent oxidoreductase that plays a critical role in the major oxidative pathway of ethanol metabolism. It catalyzes the irreversible oxidation of various aldehydes, most notably acetaldehyde, into their corresponding carboxylic acids, thereby contributing to cellular detoxification and redox homeostasis. As a key enzyme in phase I and II biotransformation, ALDH1B1 is involved in broader metabolic and protein metabolism pathways. Genetic variations in the ALDH1B1 locus are associated with interindividual susceptibility to alcohol-related disorders. Clinically, the role of ALDH1B1 in acetaldehyde detoxification suggests its relevance to alcohol-induced organ damage and carcinogenesis, as well as potential links to mitochondrial diseases and certain forms of epilepsy.