人 AHI1-DT 抗体对
01AB02454
AHI1 divergent transcript (AHI1-DT) is a long non-coding RNA (lncRNA) located in a bidirectional promoter configuration with the neurodevelopmental gene AHI1. Although it does not encode a protein, AHI1-DT functions as a regulatory RNA that likely modulates the expression of its genomic neighbor and other downstream pathways. Low expression of AHI1-DT is associated with enhanced WNT signaling, increased cell-cycle progression, and chromosomal instability, suggesting a role as a putative tumor suppressor. Given its close genomic proximity to AHI1, which is essential for cerebellar and cortical development, AHI1-DT may participate in the complex regulatory architecture governing neurodevelopmental processes. Its dysregulation is implicated in oncogenic phenotypes and potentially contributes to the pathology of ciliopathies such as Joubert syndrome.
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技术参数
- 靶点基因名
- AHI1-DT
- 基因别名
- C6orf217; LINC00271; NCRNA00271
- 蛋白别名
- AHI1 divergent transcript; AHI1-DT
- UniProt
- P0C7V0
- 物种
- Human
产品详情
- 靶点名称
- AHI1-DT
- 蛋白名称
- AHI1 divergent transcript
- 蛋白别名
- Putative uncharacterized protein encoded by LINC00271; AHI1 divergent transcript
- 靶点基因名
- AHI1-DT
- 基因别名
- C6orf217; LINC00271; NCRNA00271
- UniProt
- P0C7V0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
AHI1 divergent transcript (AHI1-DT) is a long non-coding RNA (lncRNA) located in a bidirectional promoter configuration with the neurodevelopmental gene AHI1. Although it does not encode a protein, AHI1-DT functions as a regulatory RNA that likely modulates the expression of its genomic neighbor and other downstream pathways. Low expression of AHI1-DT is associated with enhanced WNT signaling, increased cell-cycle progression, and chromosomal instability, suggesting a role as a putative tumor suppressor. Given its close genomic proximity to AHI1, which is essential for cerebellar and cortical development, AHI1-DT may participate in the complex regulatory architecture governing neurodevelopmental processes. Its dysregulation is implicated in oncogenic phenotypes and potentially contributes to the pathology of ciliopathies such as Joubert syndrome.