抗人 AHCY 抗体对
01AB02781
Adenosylhomocysteinase (AHCY) is a cytosolic, NAD+-dependent enzyme that catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine (SAH) into adenosine and homocysteine. By removing SAH, which is a potent competitive inhibitor of S-adenosyl-L-methionine-dependent methyltransferases, AHCY serves as a key regulator of cellular methylation potential and one-carbon metabolism. The enzyme functions as a tetramer with a tightly bound NAD cofactor per subunit, acting as a metabolic gatekeeper for redox balance and epigenetic regulation. Pathogenic mutations in AHCY cause AHCY deficiency, a condition characterized by elevated plasma methionine and SAH levels, delayed myelination, myopathy, and psychomotor retardation.
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技术参数
- 靶点基因名
- AHCY
- 基因别名
- SAHH
- 蛋白别名
- adenosylhomocysteinase; AHCY
- UniProt
- P23526
- 物种
- Human
产品详情
- 靶点名称
- AHCY
- 蛋白名称
- adenosylhomocysteinase
- 蛋白别名
- Adenosylhomocysteinase; AdoHcyase; S-adenosyl-L-homocysteine hydrolase
- 靶点基因名
- AHCY
- 基因别名
- SAHH
- UniProt
- P23526
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Adenosylhomocysteinase (AHCY) is a cytosolic, NAD+-dependent enzyme that catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine (SAH) into adenosine and homocysteine. By removing SAH, which is a potent competitive inhibitor of S-adenosyl-L-methionine-dependent methyltransferases, AHCY serves as a key regulator of cellular methylation potential and one-carbon metabolism. The enzyme functions as a tetramer with a tightly bound NAD cofactor per subunit, acting as a metabolic gatekeeper for redox balance and epigenetic regulation. Pathogenic mutations in AHCY cause AHCY deficiency, a condition characterized by elevated plasma methionine and SAH levels, delayed myelination, myopathy, and psychomotor retardation.