人 AHCTF1 抗体对
01AB01426
AT-hook containing transcription factor 1 (AHCTF1), also known as ELYS, is a large nuclear protein essential for the assembly of the nuclear pore complex (NPC) during the exit from mitosis. It functions by binding to chromatin via its AT-hook motifs and recruiting the Nup107–160 subcomplex, thereby initiating NPC formation on decondensing chromosomes. AHCTF1 is also required for the proper kinetochore localization of the Nup107–160 subcomplex during mitosis and is critical for the successful completion of cytokinesis. By linking nuclear envelope reformation with chromosome segregation, it ensures genomic stability during cell division. Clinically, dysregulation of AHCTF1 is associated with autoimmune lymphoproliferative syndrome, suggesting that this nuclear assembly factor plays a vital role in maintaining immune homeostasis and preventing aberrant lymphocyte proliferation.
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技术参数
- 靶点基因名
- AHCTF1
- 基因别名
- ELYS; TMBS62
- 蛋白别名
- AT-hook containing transcription factor 1; AHCTF1
- UniProt
- Q8WYP5
- 物种
- Human
产品详情
- 靶点名称
- AHCTF1
- 蛋白名称
- AT-hook containing transcription factor 1
- 蛋白别名
- Protein ELYS; Embryonic large molecule derived from yolk sac; Protein MEL-28; Putative AT-hook-containing transcription factor 1
- 靶点基因名
- AHCTF1
- 基因别名
- ELYS; TMBS62
- UniProt
- Q8WYP5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
AT-hook containing transcription factor 1 (AHCTF1), also known as ELYS, is a large nuclear protein essential for the assembly of the nuclear pore complex (NPC) during the exit from mitosis. It functions by binding to chromatin via its AT-hook motifs and recruiting the Nup107–160 subcomplex, thereby initiating NPC formation on decondensing chromosomes. AHCTF1 is also required for the proper kinetochore localization of the Nup107–160 subcomplex during mitosis and is critical for the successful completion of cytokinesis. By linking nuclear envelope reformation with chromosome segregation, it ensures genomic stability during cell division. Clinically, dysregulation of AHCTF1 is associated with autoimmune lymphoproliferative syndrome, suggesting that this nuclear assembly factor plays a vital role in maintaining immune homeostasis and preventing aberrant lymphocyte proliferation.