人 AGR3 抗体对
01AB04211
Anterior gradient 3, protein disulphide isomerase family member (AGR3) is a protein encoded by the AGR3 gene. It belongs to the disulfide isomerase (PDI) family of endoplasmic reticulum proteins that catalyze protein folding and thiol-disulfide interchange reactions. The protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. AGR3 is expressed in ciliated airway epithelial cells and plays a role in ciliary beat frequency in multiciliated cells. It is also over-expressed in breast, ovarian, and prostate cancers, and has been implicated in promoting tamoxifen resistance in breast cancer by activating the estrogen receptor signaling pathway.
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技术参数
- 靶点基因名
- AGR3
- 基因别名
- BCMP11; PDIA18
- 蛋白别名
- anterior gradient 3, protein disulphide isomerase family member; AGR3
- UniProt
- Q8TD06
- 物种
- Human
产品详情
- 靶点名称
- AGR3
- 蛋白名称
- anterior gradient 3, protein disulphide isomerase family member
- 蛋白别名
- Anterior gradient protein 3; AG-3; AG3; hAG-3; Anterior gradient 3 homolog; Breast cancer membrane protein 11; Protein disulfide isomerase family A; member 18
- 靶点基因名
- AGR3
- 基因别名
- BCMP11; PDIA18
- UniProt
- Q8TD06
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Anterior gradient 3, protein disulphide isomerase family member (AGR3) is a protein encoded by the AGR3 gene. It belongs to the disulfide isomerase (PDI) family of endoplasmic reticulum proteins that catalyze protein folding and thiol-disulfide interchange reactions. The protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. AGR3 is expressed in ciliated airway epithelial cells and plays a role in ciliary beat frequency in multiciliated cells. It is also over-expressed in breast, ovarian, and prostate cancers, and has been implicated in promoting tamoxifen resistance in breast cancer by activating the estrogen receptor signaling pathway.