抗人 Aggrecan 抗体对
01AB03925
Aggrecan core protein (ACAN) is a large proteoglycan predominantly found in cartilage, playing a vital role in maintaining the structural integrity and resilience of the extracellular matrix. It consists of a core protein with multiple glycosaminoglycan (GAG) chains, primarily chondroitin sulfate and keratan sulfate, which contribute to its ability to retain water and provide compressive strength to cartilage. ACAN is essential for normal cartilage function, facilitating the mechanical properties necessary for joint movement and load-bearing. Beyond its structural role, ACAN also participates in signaling pathways that regulate cell behavior and tissue homeostasis. Dysregulation or mutations in the ACAN gene have been linked to various skeletal disorders, including osteoarthritis and multiple forms of skeletal dysplasia, where impaired cartilage function leads to joint pain and mobility issues.
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技术参数
- 靶点基因名
- ACAN
- 基因别名
- AGC1; CSPG1; MSK16
- 蛋白别名
- aggrecan; Aggrecan
- UniProt
- P16112
- 物种
- Human
产品详情
- 靶点名称
- Aggrecan
- 蛋白名称
- aggrecan
- 蛋白别名
- Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]
- 靶点基因名
- ACAN
- 基因别名
- AGC1; CSPG1; MSK16
- UniProt
- P16112
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Aggrecan core protein (ACAN) is a large proteoglycan predominantly found in cartilage, playing a vital role in maintaining the structural integrity and resilience of the extracellular matrix. It consists of a core protein with multiple glycosaminoglycan (GAG) chains, primarily chondroitin sulfate and keratan sulfate, which contribute to its ability to retain water and provide compressive strength to cartilage. ACAN is essential for normal cartilage function, facilitating the mechanical properties necessary for joint movement and load-bearing. Beyond its structural role, ACAN also participates in signaling pathways that regulate cell behavior and tissue homeostasis. Dysregulation or mutations in the ACAN gene have been linked to various skeletal disorders, including osteoarthritis and multiple forms of skeletal dysplasia, where impaired cartilage function leads to joint pain and mobility issues.