人 AFAP1L2 抗体对
01AB02622
Actin filament associated protein 1 like 2 (AFAP1L2), also known as XB130, is a cytosolic adaptor protein that facilitates communication between receptor and non-receptor tyrosine kinases and their downstream signaling pathways. It contains multiple tyrosine phosphorylation sites and proline-rich regions that enable SH2 and SH3 domain binding. AFAP1L2 acts as a protein tyrosine kinase activator, specifically enhancing SRC kinase activity and contributing to SRC-regulated transcription. It is involved in the regulation of gene expression, the mitotic cell cycle, and cytoskeletal signaling. By localizing to lamellipodia and influencing PI3K/Akt signaling, AFAP1L2 plays a significant role in modulating cell proliferation, survival, motility, and invasive potential.
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技术参数
- 靶点基因名
- AFAP1L2
- 基因别名
- KIAA1914; XB130
- 蛋白别名
- actin filament associated protein 1 like 2; AFAP1L2
- UniProt
- Q8N4X5
- 物种
- Human
产品详情
- 靶点名称
- AFAP1L2
- 蛋白名称
- actin filament associated protein 1 like 2
- 蛋白别名
- Actin filament-associated protein 1-like 2; AFAP1-like protein 2
- 靶点基因名
- AFAP1L2
- 基因别名
- KIAA1914; XB130
- UniProt
- Q8N4X5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Actin filament associated protein 1 like 2 (AFAP1L2), also known as XB130, is a cytosolic adaptor protein that facilitates communication between receptor and non-receptor tyrosine kinases and their downstream signaling pathways. It contains multiple tyrosine phosphorylation sites and proline-rich regions that enable SH2 and SH3 domain binding. AFAP1L2 acts as a protein tyrosine kinase activator, specifically enhancing SRC kinase activity and contributing to SRC-regulated transcription. It is involved in the regulation of gene expression, the mitotic cell cycle, and cytoskeletal signaling. By localizing to lamellipodia and influencing PI3K/Akt signaling, AFAP1L2 plays a significant role in modulating cell proliferation, survival, motility, and invasive potential.