人 ADIRF 抗体对
01AB03293
Adipogenesis regulatory factor (ADIRF) is a small secreted protein highly enriched in mature adipocytes that serves as a key regulator of fat cell development. It promotes adipogenic differentiation by stimulating the transcription of master regulators, including PPARG and CEBPA, particularly during the early stages of preadipocyte maturation. By upregulating these transcriptional pathways, ADIRF facilitates the formation of white adipose tissue. Beyond its role in adipogenesis, ADIRF expression is modulated by epigenetic mechanisms and has been implicated in the malignant transformation of bronchial epithelial cells. High expression levels of ADIRF are also associated with increased resistance to cisplatin-based chemotherapy in certain cancer contexts.
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技术参数
- 靶点基因名
- ADIRF
- 基因别名
- AFRO; APM2; C10orf116
- 蛋白别名
- adipogenesis regulatory factor; ADIRF
- UniProt
- Q15847
- 物种
- Human
产品详情
- 靶点名称
- ADIRF
- 蛋白名称
- adipogenesis regulatory factor
- 蛋白别名
- Adipogenesis regulatory factor; Adipogenesis factor rich in obesity; Adipose most abundant gene transcript 2 protein; Adipose-specific protein 2; apM-2
- 靶点基因名
- ADIRF
- 基因别名
- AFRO; APM2; C10orf116
- UniProt
- Q15847
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Adipogenesis regulatory factor (ADIRF) is a small secreted protein highly enriched in mature adipocytes that serves as a key regulator of fat cell development. It promotes adipogenic differentiation by stimulating the transcription of master regulators, including PPARG and CEBPA, particularly during the early stages of preadipocyte maturation. By upregulating these transcriptional pathways, ADIRF facilitates the formation of white adipose tissue. Beyond its role in adipogenesis, ADIRF expression is modulated by epigenetic mechanisms and has been implicated in the malignant transformation of bronchial epithelial cells. High expression levels of ADIRF are also associated with increased resistance to cisplatin-based chemotherapy in certain cancer contexts.