人 ADGRG2 抗体对
01AB02464
Adhesion G protein-coupled receptor G2 (ADGRG2) is an orphan adhesion-class GPCR encoded on the X chromosome that plays a critical role in male reproductive tract function. The protein undergoes autoproteolytic cleavage at its GPCR proteolysis site to generate a large extracellular N-terminal fragment and a C-terminal seven-transmembrane fragment, which remain noncovalently associated at the apical membrane. ADGRG2 couples to multiple G proteins, including Gs, Gq, and G12/13, to activate downstream signaling pathways such as adenylyl cyclase and phospholipase C. It is highly enriched in the efferent ductules and proximal epididymis, where it regulates transepithelial fluid reabsorption and epithelial adhesion. Clinically, hemizygous mutations in ADGRG2 are a well-established cause of X-linked congenital absence of the vas deferens and obstructive azoospermia.
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技术参数
- 靶点基因名
- ADGRG2
- 基因别名
- GPR64; HE6; TM7LN2
- 蛋白别名
- adhesion G protein-coupled receptor G2; ADGRG2
- UniProt
- Q8IZP9
- 物种
- Human
产品详情
- 靶点名称
- ADGRG2
- 蛋白名称
- adhesion G protein-coupled receptor G2
- 蛋白别名
- Adhesion G-protein coupled receptor G2; G-protein coupled receptor 64; Human epididymis-specific protein 6; He6) [Cleaved into: Adhesion G-protein coupled receptor G2; N-terminal fragment; ADGRG2 N-terminal fragment); Adhesion G-protein coupled receptor G2; C-terminal fragment; ADGRG2 C-terminal fragment]
- 靶点基因名
- ADGRG2
- 基因别名
- GPR64; HE6; TM7LN2
- UniProt
- Q8IZP9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Adhesion G protein-coupled receptor G2 (ADGRG2) is an orphan adhesion-class GPCR encoded on the X chromosome that plays a critical role in male reproductive tract function. The protein undergoes autoproteolytic cleavage at its GPCR proteolysis site to generate a large extracellular N-terminal fragment and a C-terminal seven-transmembrane fragment, which remain noncovalently associated at the apical membrane. ADGRG2 couples to multiple G proteins, including Gs, Gq, and G12/13, to activate downstream signaling pathways such as adenylyl cyclase and phospholipase C. It is highly enriched in the efferent ductules and proximal epididymis, where it regulates transepithelial fluid reabsorption and epithelial adhesion. Clinically, hemizygous mutations in ADGRG2 are a well-established cause of X-linked congenital absence of the vas deferens and obstructive azoospermia.