人 ADGRF4 抗体对
01AB02118
Adhesion G protein-coupled receptor F4 (ADGRF4), also known as GPR115, is a class B2 adhesion GPCR characterized by a large extracellular region and a GAIN domain. It typically undergoes autoproteolytic cleavage to form noncovalently associated fragments that regulate receptor activation and transmembrane signaling. ADGRF4 is predominantly expressed in the epidermis, specifically within spinous and granular keratinocytes, where it functions as a key regulator of epidermal differentiation and KRT1 expression. This role is essential for proper keratinocyte maturation and stratification. Additionally, ADGRF4 is involved in the development of other ectodermal tissues, such as enamel mineralization by ameloblasts. Clinically, mutations in ADGRF4 have been linked to complex cortical dysplasia and other brain malformations, highlighting its broader significance in tissue development and morphogenesis.
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技术参数
- 靶点基因名
- ADGRF4
- 基因别名
- GPR115; PGR18
- 蛋白别名
- adhesion G protein-coupled receptor F4; ADGRF4
- UniProt
- Q8IZF3
- 物种
- Human
产品详情
- 靶点名称
- ADGRF4
- 蛋白名称
- adhesion G protein-coupled receptor F4
- 蛋白别名
- Adhesion G protein-coupled receptor F4; G-protein coupled receptor 115; G-protein coupled receptor PGR18
- 靶点基因名
- ADGRF4
- 基因别名
- GPR115; PGR18
- UniProt
- Q8IZF3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Adhesion G protein-coupled receptor F4 (ADGRF4), also known as GPR115, is a class B2 adhesion GPCR characterized by a large extracellular region and a GAIN domain. It typically undergoes autoproteolytic cleavage to form noncovalently associated fragments that regulate receptor activation and transmembrane signaling. ADGRF4 is predominantly expressed in the epidermis, specifically within spinous and granular keratinocytes, where it functions as a key regulator of epidermal differentiation and KRT1 expression. This role is essential for proper keratinocyte maturation and stratification. Additionally, ADGRF4 is involved in the development of other ectodermal tissues, such as enamel mineralization by ameloblasts. Clinically, mutations in ADGRF4 have been linked to complex cortical dysplasia and other brain malformations, highlighting its broader significance in tissue development and morphogenesis.